Proposed Mechanisms For Aspirin and Other NSAIDs Reduction of Cancer Risk

This post will be short.

Every once in awhile I come across a journal article that I feel establishes a new reference point for understanding of a phenomenon.

This article is one of those them – http://onlinelibrary.wiley.com/doi/10.1002/ijc.22899/pdf , and you can get a copy of it for free.

It is a review article, and pulls together a lot of other teams’ research results to support their proposal of two paths through which COX-2 enzyme pathways and the P53 tumor suppressor protein might interact to allow or prevent cancer occurence. It also discusses how the NSAIDs, aspirin, and COX2 Inhibitors might impact these two pathways to lower cancer risk.

The reference for the article is:

Emanuela de Moraes, Nazir Ahmad Dar, Claudia Vitoria de Moura Gallo, and Pierre Hainaut. 2007. Cross-talks between cyclooxygenase-2 and tumor suppressor protein p53: Balancing life and death during inflammatory stress and carcinogenesis. Int J Cancer: 121, 929-937.

The reading is a little challenging if you’re not a pharmacist, scientist, etc… but… I think lots of people might find it interesting anyway.

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